Tablets and hard gelatin capsules constitute a major portion of drug delivery systems that are currently available. However, many patient groups such as the elderly, children, and patients who are mentally retarded, uncooperative, nauseated or on reduced liquid-intake / diets have difficulties swallowing these dosage forms. Those who are traveling or have little access to water are similarly affected. For these reasons; tablets which can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. Rapidly dissolving or disintegrating tablets are not only indicated for people who have swallowing difficulties, but also are ideal for active people. These dosage forms rapidly disintegrate in contact with saliva within less than 60 seconds. The aim of this article is to review the advantages, disadvantages of mouth dissolving tablets, common excipients used in the formulation highlighting the use of super disintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose. Key words: MDT, Drug delivery, Superdisintegrants.
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