Tablets and hard gelatin capsules constitute a major portion of drug delivery systems that are currently available. However, many patient groups such as the elderly, children, and patients who are mentally retarded, uncooperative, nauseated or on reduced liquid-intake / diets have difficulties swallowing these dosage forms. Those who are traveling or have little access to water are similarly affected. For these reasons; tablets which can rapidly dissolve or disintegrate in the oral cavity have attracted a great deal of attention. Rapidly dissolving or disintegrating tablets are not only indicated for people who have swallowing difficulties, but also are ideal for active people. These dosage forms rapidly disintegrate in contact with saliva within less than 60 seconds. The aim of this article is to review the advantages, disadvantages of mouth dissolving tablets, common excipients used in the formulation highlighting the use of super disintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose. Key words: MDT, Drug delivery, Superdisintegrants.
The current manuscript describes an overview for therapeutic approaches to treat diabetes mellitus. Detailed presentation of the role of insulin in both disease state development and therapy is given. The article also addresses the classification, chemistry, pharmacokinetic properties, dosage forms, mechanisms of action, and therapeutic indications of oral anti-diabetic agents currently available for clinical use. The paper also details the rationale of differences in the onset and duration of action of various insulin preparations. The paper also briefly addresses the phenomena of development of insulin resistance, multiingredient dosage form of oral anti-diabetic agents, and approaches to teaching the topic in the classroom.
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